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The liver helps to excrete it. High levels of bilirubin can lead to jaundice. High bilirubin levels can occur in adults, but the disorder is more common in newborn infants.

This is because it takes some time after birth for an infant to start efficiently metabolizing bilirubin and excreting it in their stool. The approximate normal range of bilirubin in the blood serum is:.

Any person who experiences yellowing of the skin or eyes should see their doctor. It may be a sign of a serious condition. High bilirubin levels can cause jaundice.

Jaundice makes the skin and the whites of the eyes appear yellow, due to the brown and yellow bilirubin in the blood. The breakdown of red blood cells RBCs in the body produces bilirubin.

The bilirubin travels to the liver and is stored in the bile duct. The body ultimately expels bilirubin in stools. The RBCs have a lifespan of around days and renew continually.

RBCs contain hemoglobin, which helps transport oxygen around the body, and it is this that gets broken down into bilirubin and other substances.

The bilirubin is carried to the liver by albumin, a simple protein. Unconjugated bilirubin is toxic, but conjugated bilirubin is usually not, because it can be removed from the body, as long as nothing is interfering with its removal.

Hemolytic anemia occurs when too many red blood cells are broken down before the end of their natural life cycle. If the liver is not working properly, it may be unable to make bilirubin water-soluble.

This may result in too much bilirubin building up in the liver. Once the bilirubin has left the liver, levels may be high because the bilirubin is unable to leave the body.

This may be a result of blockage in one of the other organs that assist excretion, such as gallstones in the gallbladder. This is called the post-hepatic phase.

Blood tests can measure bilirubin levels. While there is a urine test for bilirubin, it is less accurate and often falsely positive.

If a routine urine test detects bilirubin, a doctor will look at blood serum tests to confirm the results and identify any damage to the liver.

This may occur, for example, with:. Rare inherited disorders that cause abnormal bilirubin metabolism such as Rotor, Dubin-Johnson, and Crigler-Najjar syndromes, may also cause increased levels of bilirubin.

Increased total and unconjugated bilirubin levels are relatively common in newborns in the first few days after birth. This finding is called "physiologic jaundice of the newborn" and occurs because the newborn's liver is not mature enough to process bilirubin yet.

Usually, physiologic jaundice of the newborn is temporary and resolves within a few days to two weeks. However, if the bilirubin level is critically high or increases rapidly, the healthcare practitioner will diagnose the cause so appropriate treatment can be started as soon as possible.

A rare about 1 in 12, births but life-threatening congenital condition called biliary atresia can cause increased total and conjugated bilirubin levels in newborns.

This condition must be quickly diagnosed and treated, usually with surgery, to prevent serious liver damage that may require liver transplantation within the first few years of life.

Some children may require liver transplantation despite early surgical treatment. Bilirubin testing is included as part of the common dipstick tests used in a routine urinalysis.

Bilirubin is not normally present in the urine. However, conjugated bilirubin is water-soluble and may be eliminated from the body through the urine if it cannot pass into the bile.

If bilirubin is detected in the urine, it usually means your liver or bile ducts are blocked or you have hepatitis or some other form of liver damage.

In these cases, bilirubin may be detectable in the urine early in the disease. Yes, several inherited chronic conditions can increase bilirubin levels in the blood.

These include:. The first three are usually mild, chronic conditions that can be aggravated under certain conditions but in general cause no significant health problems.

For example, Gilbert syndrome is very common; about 1 in every 6 people has this genetic abnormality, but usually people with Gilbert syndrome do not have elevated bilirubin.

Crigler-Najjar syndrome is the most serious inherited condition listed; this disorder is relatively rare, and some people with it may die.

Treatment depends on the cause of the jaundice. In Gilbert, Rotor, and Dubin-Johnson syndromes, no treatment is usually necessary. Crigler-Najjar syndrome may respond to certain enzyme drug therapy or may require a liver transplant.

Jaundice caused by an obstruction is often resolved by surgery. Though unconjugated bilirubin may be toxic to brain development in newborns up to weeks of age , it does not pose the same threat to older children and adults.

In older children and adults, the "blood-brain barrier" is more developed and prevents bilirubin from moving from the blood into the brain and affecting brain cells.

Nevertheless, elevated bilirubin strongly suggests that a medical condition is present that must be evaluated and treated.

Bilirubin concentrations tend to be slightly higher in males than females. African Americans routinely show lower bilirubin concentrations than non-African Americans.

Strenuous exercise may increase bilirubin levels. Drugs that can decrease total bilirubin include barbiturates, caffeine, penicillin, and high doses of salicylates.

The drug atazanavir increases unconjugated indirect bilirubin. You may be able to find your test results on your laboratory's website or patient portal.

However, you are currently at Lab Tests Online. You may have been directed here by your lab's website in order to provide you with background information about the test s you had performed.

Lab Tests Online is an award-winning patient education website offering information on laboratory tests. The reference ranges for your tests can be found on your laboratory report.

They are typically found to the right of your results. If you do not have your lab report, consult your healthcare provider or the laboratory that performed the test s to obtain the reference range.

Laboratory test results are not meaningful by themselves. Their meaning comes from comparison to reference ranges.

Reference ranges are the values expected for a healthy person. They are sometimes called "normal" values. By comparing your test results with reference values, you and your healthcare provider can see if any of your test results fall outside the range of expected values.

Values that are outside expected ranges can provide clues to help identify possible conditions or diseases.

While accuracy of laboratory testing has significantly evolved over the past few decades, some lab-to-lab variability can occur due to differences in testing equipment, chemical reagents, and techniques.

This is a reason why so few reference ranges are provided on this site. It is important to know that you must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits.

It provides a common language to unambiguously identify things you can measure or observe that enables the exchange and aggregation of clinical results for care delivery, outcomes management, and research.

Learn More. Please note when you click on the hyperlinked code, you are leaving Lab Tests Online and accessing Loinc. National Library of Medicine.

Accessed October Wehbi, Mohammad. Kalakonda, Aditya, Savio, John. National Center for Biotechnology Information. Hemolytic Disease of the Newborn.

Children's Hospital of Philadelphia. Centers for Disease Control and Prevention. Vitek, L. Physiological Research.

The Cleveland Clinic. Jaundice online information. Accessed March KidsHealth, Nemours Foundation. Jaundice in Healthy Newborns online information.

Pagana K, Pagana T. Mosby's Manual of Diagnostic and Laboratory Tests. Louis: Mosby Elsevier; Pp. Britannica Quiz. What is the name of the tissue that connects muscle to bone?

Learn More in these related Britannica articles:. This condition is evident in three different types of disorders, more than one of which may be present simultaneously in a single person.

The first type, unconjugated, or hemolytic, jaundice, appears when the amount of bilirubin produced…. In certain conditions in which there is a rapid rate of destruction of red blood cells, the inability of the liver to excrete the added load of bilirubin may….

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Having high bilirubin can be a sign of several conditions. Your doctor will take your symptoms, as well as any other test results, into account to help narrow down a diagnosis.

Gallstones happen when substances like cholesterol or bilirubin harden in your gallbladder. Your gallbladder is responsible for making bile, a digestive fluid that helps break down fats before they enter your intestines.

They can also be a complication of an infection of your bile ducts or from a blood disorder. This causes it to build up in your blood stream.

Any condition that affects the function of your liver can cause bilirubin to build up in your blood. This is a result of your liver losing its ability to remove and process bilirubin from your bloodstream.

Hepatitis happens when your liver gets inflamed, often due to a viral infection. Your bile ducts connect your liver to your gallbladder the opening of your small intestine, called the duodenum.

They help to move bile, which contains bilirubin, from your liver and gallbladder into your intestines. This can lead to an increased level of bilirubin.

Intrahepatic cholestasis of pregnancy is a temporary condition that can happen during the last trimester of pregnancy.

It causes bile drainage from your liver to either slow down or stop entirely. This makes it harder for your liver to process bilirubin from your blood, leading to high bilirubin levels.

Hemolytic anemia happens when blood cells break down too quickly in your bloodstream. But if you notice any of the following symptoms, call your doctor or head to urgent care just in case:.

Anyone with jaundice, the main sign of high bilirubin levels, needs to see their doctor. The liver produces and clears cholesterol in the body.

Learn how liver damage can affect cholesterol and what treatments you can explore. Liver function tests help screen for problems such as infections, scarring, and disorders.

They're also used if you start experiencing symptoms of a…. Your liver processes everything you eat and drink. And if you have jaundice, your diet can either help or hurt your symptoms.

Here's what you can do. A common condition, it can occur when babies have a high level of bilirubin, a yellow…. Damage to the liver from excessive drinking can lead to ARLD.

Years of alcohol abuse cause the liver to become inflamed and swollen. The liver is divided into a large right lobe and a small left lobe.

The division is made by the attachment of the falciform ligament. The right lobe…. The connection between the left and right hepatic ducts forms the common hepatic duct, whose function is to drain bile from the liver.

This duct is an…. The intermediate branch of hepatic artery is one of the smaller arterial segments that provides blood supply to the internal structures of the liver….

These results may vary slightly from laboratory to laboratory. Normal results may be slightly different for women and children, and results may be affected by certain foods, medications or strenuous exercise.

Be sure to tell your doctor about any foods or medications you've taken and your activity levels so that your results can be interpreted correctly.

Lower than normal bilirubin levels are usually not a concern. Elevated levels may indicate liver damage or disease. Higher than normal levels of direct bilirubin in your blood may indicate your liver isn't clearing bilirubin properly.

Elevated levels of indirect bilirubin may indicate other problems. One common, and harmless, cause of elevated bilirubin is Gilbert's syndrome, a deficiency in an enzyme that helps break down bilirubin.

Your doctor may order further tests to investigate your condition. Bilirubin test results also may be used to monitor the progression of certain conditions such as jaundice.

Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission.

This content does not have an English version. This content does not have an Arabic version. Sections for Bilirubin test About.

Request an appointment. Overview Bilirubin testing checks for levels of bilirubin in your blood. More Information Gilbert's syndrome.

Request an Appointment at Mayo Clinic. Share on: Facebook Twitter. Show references Bilirubin, serum. Mayo Medical Laboratories.

Accessed Aug. Lab Tests Online. Friedman LS. Clinical aspects of serum bilirubin determination.

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